Anovulatory infertility should prompt investigation and treatment of endocrinopathies. With monitoring, ovulation induction using oral or injectable medications results in good pregnancy rates and has a low risk of multiple pregnancy.
- Oligomenorrhoea or amenorrhoea are hallmark signs of anovulation.
- Identifying and correcting underlying endocrine disorders are the first steps in treating anovulation, before initiating targeted ovulation induction therapies.
- Clomifene and letrozole are effective treatments for anovulation in polycystic ovary syndrome.
- Follicle stimulating hormone and luteinising hormone injections may be required, especially for hypogonadotropic hypogonadism.
- Single ovulation is the goal of treatment.
- Referral of the patient to a fertility specialist is recommended for ovulation induction with gonadotropins or if other fertility factors exist.