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Perspectives

Ovulation induction: when and how to use it

Vicki Nisenblat, M. Louise Hull

Figures

© Jennifer N. Gentry
© Jennifer N. Gentry

Abstract

Anovulatory infertility should prompt investigation and treatment of endocrinopathies. With monitoring, ovulation induction using oral or injectable medications results in good pregnancy rates and has a low risk of multiple pregnancy.

Key Points

  • Oligomenorrhoea or amenorrhoea are hallmark signs of anovulation.
  • Identifying and correcting underlying endocrine disorders are the first steps in treating anovulation, before initiating targeted ovulation induction therapies.
  • Clomifene and letrozole are effective treatments for anovulation in polycystic ovary syndrome.
  • Follicle stimulating hormone and luteinising hormone injections may be required, especially for hypogonadotropic hypogonadism.
  • Single ovulation is the goal of treatment.
  • Referral of the patient to a fertility specialist is recommended for ovulation induction with gonadotropins or if other fertility factors exist.

Figures

© Jennifer N. Gentry
© Jennifer N. Gentry